Which of the Following Statements Best Describes the Release of Lipophobic

Which of the following statements best describes the release of lipophobic messengers?

A) Lipophobic messengers are stored in vesicles and released by simple diffusion in response to a stimulus.
B) Lipophobic messengers are released immediately upon synthesis by simple diffusion.
C) Lipophobic messengers are stored free in the cytosol and released by simple diffusion in response to a stimulus.
D) Lipophobic messengers are stored in vesicles and released by exocytosis immediately after synthesis.
E) Lipophobic messengers are stored in vesicles and released by exocytosis in response to a stimulus.