Pyruvate is converted to lactate in the cytosol under anaerobic conditions, but it is converted to acetyl CoA in the mitochondrial matrix under aerobic conditions.

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Under anaerobic conditions, pyruvate is converted to lactate in the cytosol to regenerate NAD+ for glycolysis. Under aerobic conditions, pyruvate is transported into the mitochondrial matrix, where it is converted to acetyl CoA, which then enters the citric acid cycle for further energy production.

Pyruvate Is Converted to Lactate in the Cytosol Under Anaerobic