Why Do Many Diabetics Have to Have a Foot Amputated

Why do many diabetics have to have a foot amputated?

A) Decreased blood flow to the foot directly causes wounds to develop that will not heal.
B) Decreased blood flow to the foot causes extreme pain that can only be relieved by amputation.
C) Decreased blood flow to the foot causes gangrene.
D) Neuropathy causes intense pain that can only be relieved by amputation.
E) Decreased peripheral blood flow with its consequent low tissue pO2, elevated interstitial glucose levels and abnormal wound healing, coupled with lack of sensation from the foot to warn of an injury, creates a very favorable anaerobic growth environment that can lead to gangrene.