A Person Taking a Histamine (H2)blocker or a Proton Pump

A person taking a histamine (H2) blocker or a proton pump inhibitor to relieve excess stomach acid production often finds a return of symptoms that is worse with a missed dose. Which statement about the effects these medications have on gastrin is FALSE?

A) Acid blockers have no direct effect on gastrin, but inhibit acid production through other mechanisms.
B) High circulating levels of gastrin accompany acid- blocking medication use and, if interrupted, a pronounced rebound effect of excess stomach acid ensues.
C) Return of symptoms by excess gastrin's influence on acid production stimulates further medication use, thereby leading to a chronic consumption.
D) Decreased acid production inhibits inhibition of gastrin release into the bloodstream, thereby disrupting its negative feedback mechanism.
E) Acid- blocking medications interrupt the negative feedback on gastrin release and are therefore self- limiting in their use.