Which Characteristic(s)below Do Herpes Viruses Share

Which characteristic(s) below do herpes viruses share?

A) Generally only cause clinical symptoms in immunocompromised patients.
B) Active infections that become latent, potentially reactivating many years later.
C) Virtually impossible to grow in artificial cell culture.
D) Poor antibody response to infection and generally insensitive serologic testing.
E) All of the above.