Specialized antigen- presenting cells such as macrophages, dendritic cells, and B cells are the only cells to possess class II MHC antigens, while almost all of the remaining nucleated cells in the body possess class I MHC antigens.

Question

Quizplus · Accepted Answer

Class II MHC antigens are indeed primarily expressed by specialized antigen-presenting cells such as macrophages, dendritic cells, and B cells, which play a key role in the immune response by presenting antigens to T cells. In contrast, Class I MHC antigens are found on almost all nucleated cells in the body, allowing these cells to present endogenous antigens to cytotoxic T cells.

Specialized Antigen- Presenting Cells Such as Macrophages, Dendritic Cells, and B