What Is the Primary Reason Internal Homeostasis Must Be Maintained

What is the primary reason internal homeostasis must be maintained?

A) Homeostasis prevents the wasting of stockpiles of coenzymes.
B) Unregulated variations cause the cellsʹ DNA to mutate.
C) Enzymes must retain their correct three-dimensional structure.
D) Wide swings in the internal environment interfere with normal metabolic reactions.
E) Most organisms have not evolved mechanisms to control positive feedback systems.