A single sympathetic preganglionic axon has many axon collaterals (branches) that can synapse with 20 or more postganglionic neurons. This divergence helps explain how sympathetic responses can affect most body parts simultaneously.

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This is because the branching allows a single preganglionic neuron to influence multiple postganglionic neurons, leading to a widespread effect throughout the body, characteristic of the sympathetic nervous system's "fight or flight" response.

A Single Sympathetic Preganglionic Axon Has Many Axon Collaterals (Branches)