Which of the following most accurately describes how foreign substances can activate complement?
A) Antibodies can bind to foreign antigens and activate complement through the classical pathway.
B) Foreign substances can bind to spontaneously activated C3 and stabilize it.
C) Foreign proteins bind to C1 and activate it.
D) Foreign proteins are phagocytized by macrophages and directly activate complement.
E) Both "Antibodies can bind to foreign antigens and activate complement through the classical pathway" and "Foreign substances can bind to spontaneously activated C3 and stabilize it" are correct.

Question

Quizplus · Accepted Answer

The classical pathway of complement activation is initiated when antibodies bind to foreign antigens, and the alternative pathway can be activated when foreign substances bind to and stabilize spontaneously activated C3.

Which of the Following Most Accurately Describes How Foreign Substances