Which of the Following Changes Have the Potential to Dramatically

Which of the following changes have the potential to dramatically affect the potential difference across the plasma membrane?

A) Increased permeability of the membrane to Na⁺
B) Increased intracellular concentration of K⁺
C) Any change in the rate at which the sodium-potassium pump works
D) Increased permeability of the membrane to Na⁺ and increased intracellular concentration of K⁺
E) Increased permeability of the membrane to Na⁺, increased intracellular concentration of K⁺, and any change in the rate at which the sodium-potassium pump works