A Child Ingested an Organophosphate Poison Used to Kill Insects

A child ingested an organophosphate poison used to kill insects. Soon the child's muscles began spastic contractions. Predict what occurred at the synaptic cleft.

A) Decreased release of acetylcholine from presynaptic neurons
B) Increased accumulation of acetylcholine in the synapse
C) Binding of the poison to acetylcholine receptors leading to inhibition of stimulation
D) Increased breakdown of acetylcholine in the synaptic cleft
E) Both increased accumulation of acetylcholine in the synapse and increased breakdown of acetylcholine in the synaptic cleft are correct.