The fi chain of adult hemoglobin is composed of 146 amino acids of a known sequence. In comparing the normal fi chain with the fi chain in sickle -cell hemoglobin, what alteration is one likely to find?

Question

Quizplus · Accepted Answer

In sickle-cell hemoglobin, the sixth amino acid in the beta chain is valine instead of glutamic acid, which causes the hemoglobin molecules to stick together and form fibers, leading to the sickle shape of red blood cells.

The Fi Chain of Adult Hemoglobin Is Composed of 146