One problem with both BACs and YACs is that genetic regions of these chromosomes cannot be subcloned.

Name: One problem with both BACs and YACs is that genetic regions of these chromosomes cannot be subcloned.
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Both BACs (Bacterial Artificial Chromosomes) and YACs (Yeast Artificial Chromosomes) are used precisely because they allow for the subcloning of large fragments of DNA, enabling detailed genetic analysis and manipulation.

One Problem with Both BACs and YACs Is That Genetic