The only important RBC antigens that need to be considered in human blood transfusions are the ABO antigens.

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While ABO antigens are certainly the most clinically significant in terms of blood transfusions, there are other important RBC antigens that can cause transfusion reactions or hemolytic disease of the newborn. These include Rh, Kell, Duffy, and other antigens. Therefore, it is important to match blood for a variety of antigens, not just ABO.

The Only Important RBC Antigens That Need to Be Considered