A patient takes antacids, cimetidine, and phenytoin.The health care provider prescribes a benzodiazepine for anxiety.Which drug interactions is the patient at risk for experiencing? (Select all that apply.)

Question

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A) Cimetidine inhibits the metabolism of benzodiazepines, leading to an increased plasma level and potentially increased side effects. Therefore, the patient is at risk for an increased plasma level of benzodiazepine related to cimetidine therapy.
B) Antacids can increase the pH of the stomach, which may decrease the absorption of some benzodiazepines. Therefore, there is no risk for increased absorption of the benzodiazepine if taken with an antacid.
C) Phenytoin is an antiepileptic medication that can cause adverse CNS reactions, including dizziness and drowsiness, but not euphoria and disinhibition.
D) Cimetidine inhibits the breakdown of some medications, including SSRIs, leading to an increased risk for serotonin syndrome. However, there is no risk for serotonin syndrome associated with cimetidine use in this scenario.
E) Phenytoin induces the metabolism of some medications, including benzodiazepines, potentially leading to subtherapeutic levels and decreased efficacy. Therefore, the patient is at risk for potential phenytoin toxicity.

A Patient Takes Antacids, Cimetidine, and Phenytoin