How might a change of one amino acid at a site, distant from the active site of an enzyme, alter the substrate specificity of an enzyme?
A) by changing the stability of the enzyme
B) by changing the three-dimensional conformation of the enzyme
C) by changing the optimum pH for the enzyme
D) by changing the binding site for a noncompetitive inhibitor

Question

Quizplus · Accepted Answer

A change in one amino acid at a site distant from the active site can alter the three-dimensional conformation of the enzyme, potentially altering the shape and structure of the active site, which could lead to changes in the substrate specificity of the enzyme. A change in stability, optimum pH, or binding site for a noncompetitive inhibitor would not necessarily affect substrate specificity.

How Might a Change of One Amino Acid at a Site