Which of the Following Is an Advantage of Whole-Genome Shotgun

Which of the following is an advantage of whole-genome shotgun sequencing compared to map-based sequencing?

A) The shotgun approach does not require the use of plasmids.
B) The shotgun approach is highly automated.
C) Because of the efficiency of the shotgun approach,the genome is sequenced only one time.
D) All of the above are advantages of the shotgun approach.