If removal of a DNA sequence disrupts chromosome segregation and reinsertion of the same sequence restores stable transmission,the sequence must lie within the centromere.

Question

Quizplus · Accepted Answer

The centromere is responsible for proper chromosome segregation during cell division. Therefore, if disrupting a DNA sequence within it causes problems with segregation, then the sequence must be located within the centromere. The fact that reinsertion of the same sequence restores stable transmission also supports the idea that it is centromeric in nature.

If Removal of a DNA Sequence Disrupts Chromosome Segregation and Reinsertion