The centrality-lethality rule states that
A) lethality of cancer cells is central to their evolutionary persistence.
B) yeast colonies nearest to the center of a petri dish have the lowest viability.
C) the amino acids at the center of a folded protein can cause lethality if unfolding occurs.
D) no two proteins at the center of a protein interaction network can exist in the same cell.
E) hub proteins are likely to be essential for viability.

Question

Quizplus · Accepted Answer

The centrality-lethality rule states that hub proteins, which have high centrality in protein interaction networks, are likely to be essential for the viability of the organism. This is because the disruption of hub proteins can have widespread effects on the network, leading to lethality.

The Centrality-Lethality Rule States That