Heteroplasmic cells lead to earlier appearance of mitochondrially inherited disease compared to homoplasmic cells.

Question

Quizplus · Accepted Answer

Heteroplasmic cells contain a mix of normal and mutated mitochondrial DNA (mtDNA), which can sometimes delay or reduce the severity of mitochondrially inherited diseases, compared to homoplasmic cells that contain only mutated mtDNA, often leading to an earlier appearance and potentially more severe manifestation of the disease.

Heteroplasmic Cells Lead to Earlier Appearance of Mitochondrially Inherited Disease