Which of the Following Is Not Likely to Result from the Loss

Which of the following is not likely to result from the loss of functional p53?

A) the appearance of homogenously staining regions on chromosomes
B) increases propensity to arrest in G₁
C) alterations in the G₁ to S checkpoint
D) an increase in gene amplification in affected cells
E) generation of fragments of chromosomal DNA lacking telomeres and centromeres