Which Mutation in the β-Globin Gene Could,in Theory,be Detected with a Genomic

Which mutation in the β-globin gene could,in theory,be detected with a genomic clone but not with a cDNA clone?

A) a point mutation that changes a single amino acid
B) a mutation that prevents removal of one intron
C) a promoter mutation that prevents transcription
D) a 10 bp deletion in an exon
E) a frameshift mutation