Regions of DNA are most sensitive to DNase digestion when A) they are free of histones. B) they are maintained as chromatin. C) the nuclei in which they are contained enter prophase. D) a cell is in G₀. E) found at a recombination hotspot.

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DNase is an enzyme that cleaves DNA, but it can only access the nucleotide sequences that are free of histones. In chromatin, DNA is wrapped tightly around histone proteins, which makes it inaccessible to DNase. Therefore, DNA regions that are free of histones are most sensitive to DNase digestion.

Regions of DNA Are Most Sensitive to DNase Digestion When