Water Loss Through the Epidermis Could Cause a Serious Threat

Water loss through the epidermis could cause a serious threat to health and well-being. Which of the following protects us against excessive water loss through the skin?

A) Glycolipids that are secreted by keratinocytes into extracellular spaces.
B) The dermis is the thickest portion of the skin and water cannot pass through it.
C) Fat associated with skin prevents water loss.
D) The size and shape of the cells that make up the stratum spinosum, as well as the thick bundles of intermediate filaments.