Which of the following substituted cyclohexanes has the most negative value of DG$\degree$ for ring flipping from the conformation in which the substituent is axial to the one where it is equatorial?

Question

Quizplus · Accepted Answer

Isopropylcyclohexane has the most negative value of DGF1F1F1S1F1F1F10 for ring flipping from axial to equatorial conformation due to its bulky substituent, which experiences more steric hindrance when in the axial position. The other substituents, such as methyl, chlorine, and ethynyl, do not have as much steric hindrance and therefore do not result in as much destabilization when in the axial position.

Which of the Following Substituted Cyclohexanes Has the Most Negative °\degree°

Which of the Following Substituted Cyclohexanes Has the Most Negative $\degree$