Which of the following substituted cyclohexanes has the most negative value of DG$\degree$ for ring flipping from the conformation in which the substituent is axial to the one where it is equatorial?

Question

Quizplus · Accepted Answer

tert-butylcyclohexane has the largest and most hindered substituent, which stabilizes the axial conformation due to steric hindrance. When the ring flips to the equatorial conformation, the tert-butyl group is no longer hindered and experiences more favorable interactions with other substituents. As a result, the ring-flip process is more energetically favorable for tert-butylcyclohexane compared to the other substituted cyclohexanes.

Which of the Following Substituted Cyclohexanes Has the Most Negative °\degree°

Which of the Following Substituted Cyclohexanes Has the Most Negative $\degree$