Which of the Following Statements Regarding Enzymes Is NOT Correct

Which of the following statements regarding enzymes is NOT correct?

A) An enzyme is a biological catalyst that is usually a protein.
B) The active site of an enzyme can only interact with its intended substrate.
C) The ability of an enzyme to act effectively is heavily dependent on environmental factors, such as temperature and pH.
D) Most biological enzymes are highly specific, catalyzing one type of reaction only.
E) When the substrate binds to an enzyme, the enzyme's three-dimensional structure may change as the reaction proceeds.