Which Statement Best Describes the Relationship Between an Enzyme and a Reactant

Which statement best describes the relationship between an enzyme and a reactant?

A) The relationship is temporary.
B) The enzyme and the reactant molecule are both permanently changed.
C) The resultant product and the enzyme are permanently bonded together.
D) Covalent chemical bonds stabilize the relationship.
E) One enzyme typically has many reactants with which it will associate.