What Is the Primary Reason Internal Homeostasis Must Be Maintained

What is the primary reason internal homeostasis must be maintained?

A) Wide swings in the internal environment interfere with normal metabolic reactions.
B) Enzymes must retain their correct three- dimensional structure.
C) Homeostasis prevents the wasting of stockpiles of coenzymes.
D) Most organisms have not evolved mechanisms to control positive feedback systems.
E) Unregulated variations cause the cells' DNA to mutate.