It can be challenging to accurately determine incidence rate for diseases with high percentages of asymptomatic cases or when a pathogen mutates to become more infective and/or virulent.

Question

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Accurately determining the incidence rate of diseases can be challenging when there are high percentages of asymptomatic cases because these cases often go undetected and unreported. Additionally, when a pathogen mutates to become more infective and/or virulent, it can change the disease dynamics, making previous data less applicable and complicating the estimation of new incidence rates.

It Can Be Challenging to Accurately Determine Incidence Rate for Diseases