How Do Polypeptide Drugs Work

How do polypeptide drugs work?

A) They target the 50S subunit of prokaryotic ribosomes to block protein synthesis.
B) They work by inhibiting transpeptidase enzymes that are central to building peptidoglycan by forming the protein crosslinks that bind peptidoglycan's carbohydrate chains together in a chain link fence- like structure.
C) They interact with lipopolysaccharide and destabilize the outer membrane of the Gram- negative cell wall where they can then further destabilize the plasma membrane to cause cytoplasmic leakage and cell lysis.
D) They target the DNA replication enzymes DNA gyrase and topoisomerases.
E) They act as competitive inhibitors of folic acid production.