Trimethoprim- sulfamethoxazole is an antifolate drug combination that works by blocking folate production in certain bacteria as well as in certain protozoans.

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Trimethoprim-sulfamethoxazole is an antifolate drug combination that inhibits the production of folate in bacteria by blocking different steps in the folate synthesis pathway, which is essential for bacterial DNA synthesis. It is also effective against some protozoans by a similar mechanism of action.

Trimethoprim- Sulfamethoxazole Is an Antifolate Drug Combination That Works by Blocking