Which Statement Provides the Best Explanation of the Need for Self-

Which statement provides the best explanation of the need for self- tolerance screening of lymphocytes?

A) Lymphocytes which would attack the body's own tissues are never generated.
B) The process which generates the vast array of diverse antigen receptors is a random process that could produce receptors which will bind to the body's own tissues.
C) Self- tolerance involves "self" lymphocytes which bind to and form a protective layer over all body tissues.
D) It is necessary to have some lymphocytes with receptors that are self- tolerant to respond to intracellular infections by viruses.
E) The process which generates the vast array of diverse antigen receptors is a highly- controlled process, so the generation of receptors which can bind to the body's own tissues is a rare occurrence due to a genetic mutation.