Which Statement Is Not True About T Cell Subclass Differentiation

Which statement is not true about T cell subclass differentiation?

A) Regardless of which T helper cell subclass develops during an immune response, the humoral response is not impacted.
B) T cell subclass differentiation is caused by the release of cytokines that is influenced by the antigen's nature and the amount present.
C) Each subclass will include both effector and memory cells.
D) Particular combinations of cytokines will favor the development of some T cell subclasses over others.
E) Which specific T helper cell subclass that develops may impact the progression and outcome of an infectious disease.