What triggers the release of cytokines, which signal the hypothalamus of the brain to raise the body's baseline temperature from 37°C to a higher temperature?

Name: What triggers the release of cytokines, which signal the hypothalamus of the brain to raise the body's baseline temperature from 37°C to a higher temperature?
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Pyrogens are substances that trigger the release of cytokines, which in turn signal the hypothalamus to raise the body's temperature, leading to fever.

What Triggers the Release of Cytokines, Which Signal the Hypothalamus