Turning off a G-protein coupled receptor requires
A) Dissociation of the ligand from the receptor
B) Hydrolysis of GTP by the $\alpha$ subunit
C) Re-association of the $\alpha$ subunit with the $\beta$Ƴ subunit
D) Return of the activated proteins to their basal state
E) All of the above

Question

Quizplus · Accepted Answer

Turning off a G-protein coupled receptor (GPCR) involves multiple steps: the dissociation of the ligand from the receptor, which stops the activation signal; the hydrolysis of GTP to GDP by the $\alpha$ subunit, which inactivates the G-protein; the re-association of the $\alpha$ subunit with the $\beta\gamma$ subunit, which reconstitutes the inactive G-protein; and the return of the activated proteins to their basal state, ensuring the cell can respond to new signals. All these steps are necessary for the proper termination of a signal through a GPCR.

Turning Off a G-Protein Coupled Receptor Requires A) Dissociation of the Ligand

Turning Off a G-Protein Coupled Receptor Requires
A) Dissociation of the Ligand