Control of interaction of thin filament with thick filament in skeletal muscle is amplified because A) Binding of Ca to calmodulin activates CAMK phosphorylation of the myosin light chains B) Binding of Ca to TnC causes movement of tropomyosin that covers multiple myosin binding sites on the thin filament C) Greater release of Ca from the sarcoplasm ic reticulum activates m ore m yofilaments D) Ca inhibits the protein phosphatases that dephosphorylate the myosin light chains E) Repetitive stimulation keeps the [Ca²⁺] up longer

Question

Quizplus · Accepted Answer

The binding of Ca to TnC (troponin C) causes a conformational change that moves tropomyosin away from the myosin-binding sites on actin, allowing for multiple myosin heads to interact with the thin filament, thus amplifying the interaction.

Control of Interaction of Thin Filament with Thick Filament in Skeletal