Patients Who Have a Substance Use Disorder and a Chronic

Patients who have a substance use disorder and a chronic pain disorder might not respond to prescribed medications because of

A) familial pressure not to take prescribed medications because they may be addictive.
B) partial tolerance to medications being prescribed.
C) substance induced negative alterations in liver function.
D) operant conditioning in which the individual associates the use of a given compound with intravenous administration.