All of the Following Statements Are True of the Humoral

All of the following statements are true of the humoral immune response EXCEPT:

A) Most antigens activate B cells without the help of T cells.
B) IgM are the first immunoglobulins to be produced.
C) Active B cells differentiate into memory B cells and plasma cells.
D) Plasma cells produce antibodies.
E) It is a third line of defense against exogenous antigens.