Polycomb group (PcG) gene mutants cause ectopic expression of Antennapedia (Antp) and other homeotic genes. The PcG protein encoded by the PgG gene has a domain that binds to methylated histone H3. This finding supports which of the following hypotheses?
A) that PcG activates Antp genes in tissues
B) that PcG binds to Antp genes and serves as a transcription activator
C) that PcG mutants lack Antp mRNA compared to the wildtype
D) that PcG is allosteric activator of RNA polymerase II
E) that PcG repress transcription by interacting with chromatin

Question

Quizplus · Accepted Answer

PcG proteins repress transcription by modifying chromatin structure, as indicated by their ability to bind to methylated histone H3, which is a marker for transcriptionally inactive chromatin.

Polycomb Group (PcG) Gene Mutants Cause Ectopic Expression of Antennapedia