Why might the expression of a transgene be especially abnormal in vertebrates with larger average size of genes and amount of heterochromatin in their genomes?
A) homologous recombination
B) vector insufficiency
C) unequal crossing over
D) mitotic recombination
E) position effect

Question

Quizplus · Accepted Answer

The position effect refers to the phenomenon where the expression of a gene is influenced by its location within the genome. In vertebrates with larger genes and more heterochromatin, a transgene might be inserted into a region that is tightly packed or not usually expressed, leading to abnormal expression patterns. This is because heterochromatin is generally transcriptionally inactive, and the large size of genes could mean that regulatory elements are far from the transgene's insertion point, affecting its expression.

Why Might the Expression of a Transgene Be Especially Abnormal