Molecular biologists can determine experimentally whether a region of DNA contains closed chromatin or open chromatin by assessing the sensitivity of the region to__________ .
A) DNAse
B) nucleosomes
C) histone deacetylase
D) methyltransferase
E) RNA polymerase II

Question

Quizplus · Accepted Answer

DNAse sensitivity assays are used to determine whether chromatin is in an open or closed state. Open chromatin is more accessible and thus more sensitive to DNAse, which cleaves DNA, whereas closed chromatin is less accessible and more resistant to DNAse digestion.

Molecular Biologists Can Determine Experimentally Whether a Region of DNA