Mutation in the DNA Repair Checkpoint Gene TP53 Underlie Li-

Mutation in the DNA repair checkpoint gene TP53 underlie Li- Fraumeni syndrome which can be diagnosed based on _ ___________.

A) lack of mutations over many generations
B) many different types of cancer in multiple members of the same family
C) inherited breast cancer
D) recurrence of cancer in the same organ in multiple family members
E) melanoma