The 'Two- Hit' Hypothesis Suggests That _________

The 'two- hit' hypothesis suggests that _________.

A) once one allele of a gene is mutated, the other allele must be mutated in order to result in cancer
B) both eyes must contain mutations in the RB1 gene in order to develop retinoblastoma
C) two mutations in the same gene are required for that gene to become oncogenic
D) mutations in one gene promote cancer and mutations to other genes prevent cancer
E) mutations in two genes in the same cell is usually required for cancer progression