It has been estimated that the annual worldwide production of aspirin is about doses each year, a quarter of which is consumed in the United States.

Name: It has been estimated that the annual worldwide production of aspirin is about doses each year, a quarter of which is consumed in the United States.
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The annual worldwide production of aspirin is estimated to be about 100 billion doses each year, with a significant portion of this consumption occurring in the United States.

It Has Been Estimated That the Annual Worldwide Production of Aspirin