Because Membranes Usually Are Not Permeable to Polysaccharides, Nucleic Acids

Because membranes usually are not permeable to polysaccharides, nucleic acids, and proteins, how are cells able to incorporate these molecules?

A) These macromolecules are only incorporated into structures outside the membrane.
B) Macromolecules are broken down extracellularly, and their subunits diffuse through the membrane.
C) Macromolecules are digested extracellularly, and their subunits move through transport proteins.
D) Macromolecules are transported via endocytosis and digested within the cell.
E) both C and D