Li-Fraumeni syndrome is a rare inherited disease that greatly increases a person's risk of developing several types of cancer. This disease stems from a mutation in the TP53 tumor suppressor gene (Nichols et al. 2001. Cancer Epidemiol Biomarkers Prev 10:83-87). In most cases, approximately 95 percent of the mutations can be detected by sequence analysis of exons 4 through 9. If you isolated and analyzed DNA from a Li-Fraumeni patient, what genotype should you find in DNA isolated from (a) normal tissue, and (b) malignant tissue?

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The Answer of Li-Fraumeni syndrome is a rare inherited disease that greatly increases a person's risk of developing several types of cancer. This disease stems from a mutation in the TP53 tumor suppressor gene (Nichols et al. 2001. Cancer Epidemiol Biomarkers Prev 10:83-87). In most cases, approximately 95 percent of the mutations can be detected by sequence analysis of exons 4 through 9. If you isolated and analyzed DNA from a Li-Fraumeni patient, what genotype should you find in DNA isolated from (a) normal tissue, and (b) malignant tissue?

Li-Fraumeni Syndrome Is a Rare Inherited Disease That Greatly Increases