Drugs Are Metabolized Mainly by the Liver Via Phase I

Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of these types of reactions is to:

A) Inactivate prodrugs before they can be activated by target tissues
B) Change the drugs so they can cross plasma membranes
C) Change drug molecules to a form that an excretory organ can excrete
D) Make these drugs more ionized and polar to facilitate excretion