The pK_aʹs of isoleucineʹs α-Carboxyl group and α-Amino group are 2.3 and 9.8, respectively. Calculate the isoelectric point. A) 2.3 B) 6.0 C) 9.8 D) The isoelectric point cannot be calculated without the pK_avalue for the side chain.

Question

Quizplus · Accepted Answer

The isoelectric point (pI) is calculated as the average of the pKa values of the α-carboxyl and α-amino groups for amino acids without ionizable side chains. For isoleucine, pI = (2.3 + 9.8) / 2 = 6.05, which rounds to 6.0.

The PKaʹs of Isoleucineʹs α-Carboxyl Group and α-Amino Group Are

The PK_aʹs of Isoleucineʹs α-Carboxyl Group and α-Amino Group Are