Replacement of the amino acid ________ at or near an active site of an enzyme is more likely to change enzyme activity than the replacement of ________ at or near the active site.

Question

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Histidine is an amino acid commonly found in the active sites of enzymes and is often involved in catalysis. Its replacement is more likely to disrupt the activity of the enzyme compared to the replacement of other amino acids such as leucine, which is a nonpolar and neutral amino acid that may not play a significant role in the enzyme's function.

Replacement of the Amino Acid ________ at or near an Active